Xinglong Wang, Ph.D
Case Western Reserve University
Dr. Wang received his Ph.D. in pathology from the Case Western Reserve University in 2009. Following postdoctoral training at the Department of Pathology, he was promoted to Instructor of Pathology in 2011 and has became an Assistant Professor in 2013.
Alzheimer’s disease (AD) is the most prevalent form of dementia characterized by neuronal loss in the neocortex and hippocampus. Frontotemporal dementia (FTD) is the second most common form of early-onset dementia caused by neuronal loss in the frontal and temporal cortex. Amyotrophic lateral sclerosis (ALS) is the most common motor disease characterized by progressive motor neuron degeneration in brain stem and spinal cord. My research interest is to understand the mechanism(s) underlying neuronal death in various major neurodegenerative diseases with a focus on AD, FTD and ALS.
Pathomechanisms of TDP-43 neurotoxicity
Genetic mutations in TAR DNA-binding protein 43 (TDP-43) cause ALS and FTD, and the increased presence of TDP-43 in the cytoplasm is a prominent histopathological feature of degenerating neurons in ALS, FTD and AD. One major focus of our current research is about the molecular pathomechanisms of TDP-43.
Mitochondrial dysfunction in FTD and ALS
Mitochondrial dysfunction has long been recognized as a prominent feature of FTD and ALS. However, the mechanisms responsible for the mitochondrial impairment, and its role in these diseases were not clear. Mitochondria are dynamic organelles that undergo continual fission and fusion events which serve crucial physiological function. Another focus of our research is the potential role of mitochondria dynamics in mitochondrial dysfunction and neurodegeneration in FTD and ALS.