Shannon L. Macauley-Rambach, Ph.D.
Wake Forest School of Medicine
Shannon L. Macauley earned her BA in Biology and Psychology from Middlebury College (Middlebury, VT) and worked in translational neuroscience at Genzyme Corporation (Boston, MA) prior to graduate school. Dr. Macauley completed her Ph.D. in Neuroscience at Washington University (St. Louis, MO) with Dr. Mark Sands and her postdoctoral training in Alzheimer’s disease in the laboratory of Dr. David Holtzman at Washington University (St. Louis, MO). Dr. Macauley joined the Sticht Center for Healthy Aging and Alzheimer’s Prevention at Wake Forest Baptist Health as an Assistant Professor in August 2017. The goal of Dr. Macauley’s research is to understand central nervous system (CNS) disease and the secondary mechanisms of neuronal dysfunction, such as neurometabolism and neuroinflammation, which are amenable to therapeutic intervention. To date, her work has focused on two main areas: first, the study of mechanisms underlying neurodegenerative disease and the development of CNS therapeutics as it relates to lysosomal storage diseases. Second, the exploration of the link between type 2 diabetes and Alzheimer’s disease, how metabolic challenges affect normal brain function in health and disease, and how metabolic dysfunction can be targeted as a therapeutic approach for treatment of Alzheimer’s disease and diabetes.