Andrew Arrant, Ph. D.
Dr. Arrant’s research is focused on understanding the cellular mechanisms underlying neurodegenerative disease, with a focus on Frontotemporal Dementia (FTD) and Alzheimer’s disease. He is particularly interested in investigating the mechanisms driving abnormalities in mouse models to gain insight into disease, and comparing data from mouse models to patient samples. He also uses cell culture to further investigate findings from mouse models and patient samples.
Dr. Arrant studied the association of abnormal cell signaling and neuronal morphology with deficits in social behavior in a progranulin-insufficient mouse model of FTD, and have used this mouse line to test potential FTD therapies. More recently, he has begun studying endocytic trafficking and exosome secretion in FTD. Dr. arrant’s goal is to investigate how abnormal endocytic trafficking may contribute to neuronal dysfunction in FTD, and to explore the potential of exosomes as FTD biomarkers. He plans to extend these exosome studies to Alzheimer’s disease to determine if there are disease-specific changes in exosomes.